Книга "Кинетика действия ферментов. Основные принципы для поисковиков лекарств" рассказывает о том, как проводить и интерпретировать кинетические исследования ферментов для открытия и характеристики ингибиторов ферментов. Авторы начинают с простых принципов реакций ферментов с одним субстратом и их ингибиторов, затем переходят к более сложным двухсубстратным ферментам. Книга содержит множество примеров, которые помогут биохимикам, медицинским химикам и фармацевтам понять и использовать инструменты и методы для выполнения кинетических исследований в области поиска лекарств. Книга будет полезна для всех, кто работает в фармацевтической индустрии и интересуется открытием новых лекарств.
Few scientists know how to conduct the studies necessary for discovering and characterizing enzyme inhibitors for use as drugs. Kinetics of Enzyme Action, by Ross Stein, provides the foundation essential for this endeavor, starting with the simple one-substrate reaction and moving on to more complex two-substrate analyses. Divided into seven chapters, 18 case studies, a full-color schematic section, and explained with over 400 illustrative color figures, readers gain insights into screening, selection, structure-activity analysis, and structure determination of potential drug leads through enzyme studies.
Few scientists have the know-how to complete the scientific studies needed to find and characterize enzyme-inhibitors, even though pharmaceutical companies invest heavily in that research area. Initiating with the basic premises of simple one-substratum enzyme actions and their inhibitions, culminating with a vast discussion of double-substrate-enzymes, "Kinetics of Enzyme Action" teaches many steps for performing, comprehending, and explaining detailed kinetic 'trials' for pharmaceutical researching necessary for the creation of new drugs.
Электронная Книга «Kinetics of Enzyme Action. Essential Principles for Drug Hunters» написана автором Ross Stein L. в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9781118084397
Описание книги от Ross Stein L.
Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.
