Книга "Superbases for Organic Synthesis" представляет собой неоценимое руководство по использованию гуанидинов, амидинов и фосфазенов в органическом синтезе. Эти молекулы привлекают внимание химиков благодаря своей высокой щелочности и потенциальной функциональности. Они также могут быть переработаны из природных продуктов, что делает их ценными в рамках устойчивой химии, где реагенты и катализаторы получают из биоматериалов. Книга охватывает такие темы, как физико-химические свойства органических супербаз, реакции амидинов и гуанидинов в органическом синтезе, катализаторы фосфазенов, применение полимерных органических супербаз, применение супербаз в тотальном синтезе, а также рассматриваются аналоги супербаз - протонные губки и мочевинные производные. Книга представляет собой всестороннее, авторитетное и актуальное руководство по использованию этих важных реагентов для органических химиков, исследователей в области поиска лекарств и всех, кто интересуется химией природных продуктов.
This book, Superbases for organic Synthesis, by Tsutomu Ishikawa, examines organic polymers from the perspective of their use as superbasic catalysts. Guanidines, Amidines and Phosphazenes are of interest due to the great degree of basicity they can provide and also their prospective ability to catalyze reactions, with their ease of molecular modification and recyclability combined with reduced, potentially zero, toxicity. These specific molecules have the ability to occur naturally, making them prime candidates for "sustainable chemistries" where reagents or catalysts can be sourced from biological components. The book is a thorough exposition of these important ideas and molecules, covering various topics including: their physical and chemical properties, organic superbasic amine synthesis, phosphazens and their production and use as organic superelectrophilic catalysts, and polymer supported superbasic organics, among others. In conclusion, this book is an authoritative source for both organic chemists and scientists involved in drug discovery and chemistry currently working on natural product molecules.
Электронная Книга «Superbases for Organic Synthesis» написана автором Tsutomu Ishikawa в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9780470740866
Описание книги от Tsutomu Ishikawa
Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.
