Эта книга описывает создание материалов на основе коллагена. Книга была написана профессором Feng Wang и содержит множество научных исследований и описаний процессов, связанных с созданием и использованием коллагена для производства различных материалов, таких как кости, хрящи, кожа и многие другие биоматериалы. В книге также обсуждаются перспективы и возможности применения коллагена в различных областях, например, в медицине, косметической промышленности и спорте. В данной книге описываются процессы изготовления изделий из биокомпозитов, преимущества и недостатки этих материалов, а также их применение в биомедицинских исследованиях. Здесь также описаны исследования, посвященные структуре и свойствам биоматериалов.
This book focuses on the latest developments concerning collagen-derived biomaterials and their wide applications in clinical medicine. It addresses the structure, properties, and behaviors of collagen, as well as some representative collagen products that have various medical uses. For the readers without prior knowledge of the field, it also provides an introduction to collagen-related topics from a biomedical perspective. In addition, applications of collagen-based materials in cardiovascular and bone tissue engineering, enzymatic processes toward collagen degradation, and regenerative medicine are covered.
This edited volume features previously unpublished research on the development of synthetic, hybrid, and natural collagen-derived materials and devices for biomedical and tissue engineering applications. The materials included are various macromolecules found in collagens that are capable of self-assembly into scaffolds or fibers that recapitulate the properties of native tissues, such as hydrogels, xerogels, nanogels, fiber mats, and three-dimensional networks. Topics covered include insights into the formation mechanism, stimuli-responsiveness, strength of scaffolding based on collagen analogs, and the current challenges in the biomaterial fabrication, characterization, preclinical evaluation, toxicological assessment, tissue inoculation, and clinical translation. Some recent findings on three-dimensional axisymmetric fibrillar scaffold fabricated from soluble collagens are also presented. Various case reports and preclinical results achieved by bone marrow stromal cells and mesenchymal stem cells seeded on these collagen fibrous mat-like structures are provided. With the rising trend of incorporating biological molecules into synthetic materials, the resulting hybrid products are becoming more promising for tissue regeneration than conventional synthetic polymers. It covers the mechanics and applicability of cell-laden composites made from hydrogels co-polymerized with different types of collagen macros. Point of emphasis is the utility of ECM mimics in understanding biological processes and design biomimetic systems for regenerative applications, with specific coverests on muscle tissue engineered substrates, nerve guidance conduits, bone graft substitutes and heart valves. From another perspective, this book close ends at the level of predevelopment clinical trials. Case reports on applications of COL-ECM mimics to generate stable grafts, nonimmunogenic and resorbable devices, regulation of stem cells behaviour to promote differentiation and prevention of diseases-related complications, are presented. All chapters present significant contributions from leading scientific researchers worldwide. These accomplishments represent the state-of-the-art and scope of novel approaches to overcome drawbacks associated with existing solutions for tissue repair, regeneration, or reconstruction. Ultimately, applications discussed could further lead to novel theranostic approaches in diagnosis and personalized medicine that will shape the future strategies of how patients receive treatment while minimizing adverse side effects, relieving health-care burden, and maximizing improvements for patient survival from various deadliest disease categories.
Электронная Книга «Collagen-Derived Materials» написана автором Feng Wang в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9783527834501
