Книга "Foreign DNA in Mammalian Systems" ("Иностранная ДНК в млекопитающих системах") рассматривает возможность вторжения иностранной ДНК в клетки организмов и ее последствия. Иностранная ДНК определяется как генетический материал, происходящий от другого организма того же или другого вида. Естественная среда тяжело "загрязнена" такой иностранной ДНК, и млекопитающие, как и другие организмы, часто подвергаются ей в своей окружающей среде, в особенности через пищу. Пищеварительный тракт всех млекопитающих организмов по необходимости постоянно находится в контакте с иностранной ДНК. На данный момент мало что известно о механизмах защиты млекопитающих от вторжения иностранной ДНК. Однако в культуре клеток можно легко демонстрировать захват иностранной ДНК и ее геномическую фиксацию путем интеграции в геном. По ряду причин автор считает важным изучать явления и механизмы взаимодействия иностранной ДНК с клетками и организмами млекопитающих в деталях.
The established genomes o present-day organisms are unlikely to remain stable for ever. Genetic material deriving from foreign organisms—whether they be of the same species or not—might enter individual cells. This is what is called "foreign DNA". The natural environment abounds with this foreign DNA, which mammalian organisms, like others, sometimes encounter via their daily diet. The gastrointestinal tract, in particular, is in continual contact with foreign genetic material. Currently, we know very little about defense strategies employed by mammalian bodies against foreign DNA intrusions. At least, when mammalian cells are cultured, it can easily be demonstrated that genetic material is absorbed and integrated into the genome via foreign DNA acquisition. For various reasons, the writer has deemed it important to thoroughly investigate the interaction between foreign DNA and mammalian cells as well as organisms.
Электронная Книга «Foreign DNA in Mammalian Systems» написана автором Walter Doerfler в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9783527613472
Описание книги от Walter Doerfler
It is unlikely that the established genomes of present day organisms remain stable forever. It is conceivable that foreign DNA can gain entry into individual cells of an organism. Foreign DNA is defined as genetic material that derives from another organism of the same or a different species. The natural environment is heavily «contaminated» with such foreign DNA, and mammals, like other organisms, are frequently exposed to foreign DNA in their environment, notably by ingesting their daily food supply. By necessity, the gastrointestinal tract also of all mammalian organisms is constantly in contact with foreign DNA. So far, next to nothing is known about defense mechanisms in mammals against the intrusion of foreign DNA. At least in cells growing in culture, the uptake and genomic fixation by integration of foreign DNA can readily be demonstrated. For a number of reasons, the author has considered it important to investigate the phenomena and mechanisms involved in the interaction of foreign DNA with mammalian cells and organisms in detail.
