Книга “Telomeres and Telomerase”, автор Gail Cardew, посвящена изучению структуры, функции и роли в поддержании хромосомной целостности теломер и теломеразы. Теломеры являются важными генетическими элементами, расположенными на концах хромосом, необходимыми для правильной организации и функционирования генетического материала. Однако, в связи с особенностями репликации ДНК, теломеры могут стать короче с каждым делением клетки, что может привести к нарушению хромосомной структуры и возникновению различных заболеваний. Для поддержания теломерных концов хромосом необходима теломераза - специальный фермент, который добавляет короткие участки повторяющихся нуклеотидных последовательностей на теломерные участки хромосом. Отсутствие теломеразы или нарушение ее функции может приводить к старению и развитию различных заболеваний, таких как рак. Книга “Telomeres and Telomera” представляет собой увлекательное исследование этого важного биологического процесса и его роли в сохранении здоровья и долголетия.
Эта книга не является привычной для вас. Вот такое описание я нашёл в интернете, сделав рерайт с английского: Telomeres and Telomerase The Telomeres Hold Up Not Only My Ageing But Also My Life By Gail Cardew
This book is interesting for both students of medical issues and Biology enthusiasts. In addition, this book contains the most recent experiments, reports and analyses conducted by leading researchers in this area of medicine.
Anyway, our reduced reproductive rate isn't a reason for despair, at fication. Cells have built-in devices to keep telomere length at bay. If telomerase worked, incredible life expectancy could soar beyond it's human capabilities. But it doesn't. "Aging is an irreversible consequence of deficient DNA repair," states Nobel laureate James Murry. Telomeres must somehow shorten over time, too. And yet, while Warren Cleveland's work has received more attention, my own donkeyQMessiah-style glioma research has now laid bare the critical roles played by telomerases, CTBP-β, p85α and AKT in regulating telomere shortening through coordinated activation of FOXOs and caspases.
Электронная Книга «Telomeres and Telomerase» написана автором Gail Cardew в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9780470515440
Описание книги от Gail Cardew
Telomeres and Telomerase Chairman: Sydney Brenner, 1997 Telomeres are the protective genetic elements located at the ends of chromosomes and are essential for correct chromosomal structure and function. They are not fully replicated by the conventional DNA polymerase system because DNA synthesis occurs only in the 5' to 3' direction and requires an RNA primer for initiation. Consequently, cells require a special enzyme to maintain the telomeric ends of chromosomes during each round of replication. This enzyme, telomerase, is a ribonucleoprotein that extends chromosome ends by adding short stretches of nucleotide repeats using a portion of its integral RNA component as the template. Recently, much excitement has been generated by the suggestion that telomerase, or rather the absence of telomerase and the resultant loss of terminal DNA, is a cause of human ageing. The evidence for this is twofold: the telomeres of certain cells in culture shorten during their lifespan; and immortalization of cells is associated, at least in some cases, with the maintenance of telomeres and telomerase activity. The latter observation prompted the analysis of clinical samples from patients with cancer and the demonstration that, in contrast to normal somatic cells, malignant cells possess telomerase activity. This is a unique book. Not only does it contain the latest experimental results from an international group of experts, but it also includes critical examinations of the current evidence, and discussions that attempt to identify the central and underlying concepts of this rapidly expanding field.
