"Сигнальные механизмы рака" - это учебник, который поможет понять, как рак развивается на молекулярном уровне и как его можно преодолеть с помощью целевых терапий, использующих ингибиторы киназ и другие модуляторы сигнальных путей. Книга представляет собой комплексный обзор сигнальных механизмов, ответственных за развитие рака и объясняет, как они функционируют в здоровых и пораженных раком клетках. В первой части книги описываются основные механизмы образования рака, а во второй части приводится сравнение функций основных сигнальных путей, ответственных за карциногенез. Книга содержит легкочитаемый текст, а для более наглядного представления ключевых концепций и путей сигнализации рака доступны 32 видеоурока, которые можно просмотреть онлайн в электронной версии учебника. Рак стал одной из самых распространенных проблем в мире, поэтому понимание механизмов его развития является ключом к успешному лечению и улучшению результатов терапии.
Whether you are just familiar with the initial offering of this comprehensive work on cancer signaling or not, here is a summary: Cancer, having become the second leading health problem on a global basis, fundamentally resides in a malfunction in cellular signaling. A comprehensive understanding of how the intricately coordinated signaling net- works within the cells and tissues give cancer its staying power—and how they can become powerful weapons against cancer—is the key to containing, if not curing, cancer in real life, as well as improving the results of current cancer treatments.
This landmark work offers, for the first time, a gutsy tale of oncology at a molecular level and how tumor therapies that take advantage of targeting kinases and other signaling modifiers can control and even cure cancers. Part One delves into the cellular and molecular underpinnings of tumorigenesis, with emphasis on the pivotal mechanisms involved in cancer development. Part Two introduces the primary signaling tropisms that drive carcinogenesis, and compares the functions of these pathways between normal and tumor cells.
The comeliness of the subject matter of this exploration belies the ease with which this work is to be understood, making it both enjoyable academic reading and useful resource guide for all professionals in medicine, chemistry, biophysics, oncology—as well anyone else interested in battling cancer. Thirty-two specially prepared didactic videos on crucial subjects and patterns in cancer signaling form an integral part of this elevated e-book format, and are accessible online for use by users of either version of this publication.
Электронная Книга «Cancer Signaling, Enhanced Edition» написана автором Oliver Müller в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9783527800452
Описание книги от Oliver Müller
Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive – and how they can be turned into potent weapons against it – is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.
