Это первое всеобъемлющее исследование, охватывающее все фармацевтически важные темы, предоставляет комплексное введение в это новаторский и революционный инструмент, представляя как концепции, так и примеры применения биосимулированных клеток, органов и организмов. После введения в роль биосимуляции в разработке лекарств, авторы переходят к обсуждению симуляции клеток и тканей, а также моделированию действия и эффекта препаратов. Дальнейший раздел посвящен симуляции сетей и популяций, а вся книга завершается взглядом на потенциал биосимуляции в промышленной разработке лекарств и для регуляторных решений. Часть авторов являются членами сети BioSim Network of Excellence, которая охватывает более 40 академических учреждений, фармацевтических компаний и регуляторных органов, занимающихся разработкой лекарств; другие вкладчики приходят из отрасли, что приводит к междисциплинарной экспертной справочной книге.
Covering all relevant fields of pharmaceutical technology, this is the first comprehensive and thorough text providing insights into the brave new world of biosimulator technology. In detailed language that every scientist can understand, multi-author teams present the basics of simulating single cells, tissue morphology (through complex examples), modeling of how drugs and chemical compounds may act, simulating pathways and network interaction, and how regulatory bodies utilize this technology to make critical path decisions. This is practiced on an industrial scale and complemented with real-world examples of authorities working in pre-clinical phases or during drug trials.
This first comprehensive guidebook covering all important medical areas provides you with an exhaustive overview of this innovative and innovative approach, introducing concepts as well as application examples for simulated cells, organs, and bodies. The book begins with an introduction of the significance of this form of simulation in drug production and then proceeds to describe the simulation of various cells such as tumors. It also focuses on performing simulations of drugs’ effects and their impacts. Another part focuses on simulating systems and communities. It concludes its view with a glance at the feasibility of applying this procedure in the commercial production of pharmaceuticals and within regulatory decision-making matters. Several of the book’s contributors are part of the Biosism network of excellence, which includes more than forty academic organizations, pharmaceutical firms, and government regulatory bodies concerned with the development of drugs; the other contributors originate from the industry, creating a cross-discipline knowledge resource of experts.
Электронная Книга «Biosimulation in Drug Development» написана автором Martin Bertau в году.
Минимальный возраст читателя: 0
Язык: Английский
ISBN: 9783527622689
Описание книги от Martin Bertau
This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.
